Calvert Formula Calculator
Use this calculator to estimate carboplatin dose based on target AUC and renal function.
How the carboplatin AUC dose is calculated
Carboplatin is commonly dosed using the Calvert formula, which targets drug exposure (AUC) rather than only body size. The formula is:
Dose (mg) = Target AUC × (GFR + 25)
In day-to-day oncology practice, renal function is often represented by measured GFR, estimated GFR, or estimated creatinine clearance (CrCl), depending on local policy and regimen requirements.
What this calculator does
- Lets you enter a target AUC.
- Accepts either a direct renal function value or estimates CrCl via Cockcroft-Gault.
- Optionally applies a cap (commonly 125 mL/min).
- Returns a calculated carboplatin dose in mg, with optional dose rounding.
Cockcroft-Gault method used in this tool
If you choose Cockcroft-Gault mode, the calculator applies:
CrCl (male) = ((140 − age) × weight in kg) / (72 × SCr in mg/dL)
CrCl (female) = CrCl (male) × 0.85
When serum creatinine is entered in µmol/L, it is converted to mg/dL using:
SCr (mg/dL) = SCr (µmol/L) ÷ 88.4
Important clinical considerations
1) Renal function source matters
Different institutions may use measured nuclear medicine GFR, lab-reported eGFR, or Cockcroft-Gault. Your protocol determines which value is acceptable for dosing.
2) Weight selection can change CrCl
Cockcroft-Gault depends on body weight. Some centers use actual body weight, while others use adjusted or ideal body weight in selected patients. This calculator uses the weight you enter directly.
3) Capping rules vary
Capping renal function at 125 mL/min is common, but not universal. Always follow the clinical trial or local treatment pathway you are working under.
4) Rounding practices differ
Pharmacies may round to practical vial sizes (for example nearest 5 or 10 mg). Rounding should match institutional medication safety standards.
Worked example
Suppose target AUC = 5 and the protocol renal function value is 80 mL/min.
Calvert dose = 5 × (80 + 25) = 5 × 105 = 525 mg.
If your center rounds to nearest 10 mg, the final dispensed dose might be 530 mg, depending on policy and pharmacist verification.
Safety and disclaimer
This page is for learning and quick estimation only. It does not replace clinician judgment, protocol review, medication reconciliation, organ function assessment, or independent pharmacy checks. Carboplatin dosing should always be confirmed by licensed professionals before administration.