carboplatino dosis calculator

What this carboplatino dosis calculator does

This calculator helps estimate carboplatin dose using the standard Calvert method: dose is based on a target drug exposure (AUC) plus renal function. In many clinics, renal function is either measured directly (measured GFR) or estimated with Cockcroft-Gault creatinine clearance.

If you search for a carboplatino dosis calculator, you usually want a practical way to connect oncology protocol targets (for example, AUC 4, 5, or 6) with patient-specific kidney function and then output a dose in mg. This page is built exactly for that workflow.

Formulas used

1) Calvert formula

Carboplatin Dose (mg) = Target AUC × (GFR + 25)

• AUC is selected by protocol and treatment intent.
• GFR is measured directly when available, or estimated from serum creatinine.
• The constant 25 represents non-renal clearance.

2) Cockcroft-Gault estimate (when measured GFR is not entered)

This calculator can estimate creatinine clearance (CrCl) with Cockcroft-Gault:

• Male: CrCl = ((140 − age) × weight) / (72 × SCr)
• Female: multiply result by 0.85

Weight selection matters. You can choose actual body weight, ideal body weight, adjusted body weight, or Auto mode.

How to use this tool

• Enter the protocol Target AUC.
• If you have measured GFR, enter it directly (recommended when available).
• If not, enter age, sex, height, weight, and serum creatinine.
• Choose your weight method for Cockcroft-Gault estimation.
• Click Calculate Dose to get the estimated carboplatin dose in mg.

Clinical notes and practical cautions

Renal function assumptions

Estimated CrCl is a surrogate and may differ from measured GFR, especially in patients with low muscle mass, edema, amputations, or unstable renal function. For high-stakes decisions, measured renal function may be preferred.

Serum creatinine floor and GFR cap

Some protocols apply a minimum SCr value (often 0.7 mg/dL) and cap CrCl/GFR (often 125 mL/min) to avoid overdosing. This calculator lets you turn those options on or off so it can match local policy.

AUC target examples

AUC targets vary by regimen and indication. Typical values seen in practice may include 4 to 6, but exact targets depend on protocol, line of therapy, combination drugs, and institutional guidance.

Worked example

Suppose Target AUC = 5 and estimated GFR = 70 mL/min. Then dose = 5 × (70 + 25) = 5 × 95 = 475 mg.

If a measured GFR is available and differs from estimated CrCl, the final dose may change substantially. Always document which kidney function method was used.

Important disclaimer

This page is for educational and planning purposes only, not a substitute for medical judgment. Chemotherapy prescribing requires oncology oversight, protocol confirmation, lab review, toxicity assessment, and pharmacist verification before administration.